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Biomedical Science and Engineering Project 2: Testicular Cancer

BSE Research Project #2: Epigenetic impact of testicular cancer

Prof. Michael Spinella, PI
Prof. Michael Spinella, PI

Key Aims: Testicular cancer is driven by epigenetics and may be a sentinel cancer that can be leveraged to understand unifying mechanisms of PFAS-triggered tumorigenesis. Aims are to determine (i) the epigenetic alterations of TGCT cells and their tumorigenic potential and response to chemo and epigenetic therapies in response to PFAS (ii) whether PFAS alter epigenetics and progression of TGCTs in vivo.

Disease Mechanisms and Model Systems: One of the few groups in the world to pursue a mechanistic, de novo genome-wide pharmacogenetic approach to define the role of PFAS-induced polycomb pathways and DNA methylation in testicular cancer progression and response to therapy. Will utilize unique genetically engineered in vitro human cell models including unique chemotherapy and epigenetic therapy resistant testicular cells, human testicular cancer mouse xenografts, and primary human testicular cancer specimens.

Study Sites/Community: UIUC (IL), CCIL, Carle Foundation Hospital, IU School of Medicine (Indiana).

Integration: Environmental Science and Engineering Project 1 informs BSE RPs on study compounds and Environmental Science and Engineering Project 2 provides BSE2 residues from the treatment technologies for toxicology studies. Findings from BSE RPs will guide ESE RPs on detection and treatment technologies. Data Management and Analysis Core and Analytical Services Core are used for sample preparation, experiments and informatics. The Administrative Core will work with trainees in the Research Experience and Training Coordination Core on translation of epigenetic cancer therapies and science communication with the support of the Community Engagement Core.



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